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MOSA - Braindevelopment

El 01-ene.-2023 ha comenzado , continuará durante 2 años y 2 meses
Vereniging Cornelia de Lange syndroom
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Our brain processes information and determines our daily functioning. Growing and developing a brain requires great precision in the creation, docking and positioning of nerve cells. What is the consequence for this precision in making if the NIPBL gene, a key regulator in making cells, malfunctions.

Cause of Cornelia de Lange syndrome

We already know that several genes play a role in Cornelia de Lange syndrome (CdLS). The illustration below shows that NIPBL, the gene altered (mutated) in the vast majority of CdLS cases, plays a role in the so-called Cohesin Complex.

Changes in the brain

We know that in people with CdLS we often see the following:

  • smaller head circumference
  • intellectual disability
  • Problems with speech/language development
  • behavioural problems
  • seizures

Better Understanding

So it is interesting to better understand ;

  • How are the nerve cells in the brain connected?
  • How are these connections when there are healthy as well as 'sick' nerve cells (mosaicism)?
  • Which genes in the brain are all turned ON and OFF (regulated) by NIPBL?
  • How does this affect brain development?


How can we look at this?

A recent discovery has made it possible to recreate a piece of nerve tissue like the brain using 'pluripotent stem cells'. We call this 'brain organoids', which are nerve cells in 3D or 'mini-brains'.

For example, by taking a piece of skin from people with CdLS (who have a NIPBL mutation and a mosaic NIPBL mutation in particular), the researchers can "reprogramme pluripotent stem cells" from that tissue to become, for example, a heart muscle, blood stem cells, a pancreas but also nerve cells from the brain.

Making a piece of the brain in a dish

Thus, researchers can thus make brains in a dish, which they can study well for the influence of a mosaic NIPBL mutation.


Equipo de investigación y colaboradores

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Dr. Debbie van den Berg


Debbie es Professor - Principal Investigator de la Erasmus MC, Cell Biology

She managed to grow human brain organoids that allow us to investigate how structures of particular brain regions are formed, similar to what happens in the very early stages of a human embryo.


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Dr. Sylvia Huisman


Sylvia es Clinical Supervisor and Trainer de la Zodiak-Prinsenstichting, MD PhD a expertise centrum Cornelia de Lange syndroom, Medical Director a Vereniging Cornelia de Lange syndroom, (MD) Physician for ID, SIB & CdLS a International Scientific Advisory Council (SAC)

She will manage the interactions with the patients/caretakers and the CdLS family organization and help to collect tissue samples.


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PhD. Mehrnaz Ghazvini


Mehrnaz es Head iPS core facility de la Erasmus MC, iPS core facility

Mehrnaz Ghazvini and her team from the iPS core facility will derive induced pluripotent stem cells from patient samples, which we need to grow the organoids.


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PHD. Kerstin Wendt


Kerstin es Lid van de SAC de la Vereniging Cornelia de Lange syndroom, Molecular Genetics Research a International Scientific Advisory Council (SAC), Professor - Principal Investigator a Erasmus MC, Cell Biology

Together, we want to understand how mutations in the NIPBL gene affect the proper development of the human brain. An important aspect is to find out how brain development is affected when only a few cells have the mutation (mosaicism).



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