Congenital heart defects in NIPBL
- Congenital heart defects in NIPBL are frequent with Polish CdLS patients
Introduction
Mutations in NIPBL are detected in approximately 47-60% of Cornelia de Lange Syndrome (CdLS1, OMIM 122470) patients. In 20-35% patients positive for variants affecting NIPBL, congenital heart defects (CHD) are observed. 1 2 3 4 5
Materials and methods
63 patients with confirmed diagnosis of CdLS and NIPBL mutations /rearrangements were enrolled in the study. In all individuals extensive cardiologic examination was conducted.
Results
Apart from small heart defects, which resolved spontaneously during the first 2 years of life, CHDs were diagnosed in 20/63 patients (32%). The most common CHDs observed were: isolated valvular pulmonary stenosis (n=4, 6%), tetralogy of Fallot (ToF) (n=3, 5%), isolated ventricular septal defect (VSD) (n=3, 5%) and mitral insufficiency (n=3, 5%). In addition, other defects such as atrial septal defect, atrioventricular canal (AVC), aortic valve defects, and hypoplastic left heart syndrome were observed in single individuals. In eight patients (13%) significant heart defects, such as ToF, AVC, VSD, required surgery in the first year of life. One of the patients (n=1, 2%), with a most complex defect, was considered unable to have treatment and subsequently died in the neonatal period. The other 12 patients (n=12, 19%) did not require any treatment and are still under cardiologic surveillance.
Conclusions: The incidence of CHDs in a group of patients with mutations in NIPBL (32%) is significantly higher than in the general population (1%). Therefore, we recommend detailed cardiac evaluation at diagnosis for patients diagnosed with CdLS.
- ^ Ayerza Casas A, Puisac Uriol B, Teresa Rodrigo ME, Hernández Marcos M, Ramos Fuentes FJ, Pie Juste J. Cornelia de Lange syndrome: Congenital heart disease in 149 patients. Med Clin (Barc) 2017;149:300–2.
- ^ Chatfield KC, Schrier SA, Li J, Clark D, Kaur M, Kline AD, et al. Congenital heart disease in Cornelia de Lange syndrome: phenotype and genotype analysis. Am J Med Genet A 2012;158A:2499–505.
- ^ Kline AD, Moss JF, Selicorni A, Bisgaard A-M, Deardorff MA, Gillett PM, et al. Diagnosis and management of Cornelia de Lange syndrome: first international consensus statement. Nat Rev Genet 2018;19:649–66.
- ^
- Mehta AV, Ambalavanan SK. Occurrence of congenital heart disease in children withBrachmann-de Lange syndrome. Am J Med Genet 1997;71:434–5.
- ^ Selicorni A, Colli AM, Passarini A, Milani D, Cereda A, Cerutti M, et al. Analysis of congenital heart defects in 87 consecutive patients with Brachmann-de Lange syndrome. Am J Med Genet A 2009;149A:1268–72
Presenting Author: Jolanta Wierzba
Authors: Piotr Potaz 1, Jolanta Wierzba 2, Natalia Krawczyńska 3,4, Karolina Sledzińska 2, Bartosz Wasag 3,4 , Frank J. Kaiser 5 , Ilaria Parenti 5, Joanna Kwiatkowska 1
Keywords: Cornelia de Lange syndrome, NIPBL, congenital heart defects (CHD)
1) Department of Pediatric Cardiology and Congenital Heart Malformations, Medical University of Gdansk, Poland
2) Department of General Nursing, Medical University of G 3 Department of Biology and Medical Genetics, Medical University of Gdansk, Poland
3) Department of Biology and Medical Genetics, Medical University of Gdansk, Poland
4) Laboratory of Clinical Genetics, University Clinical Centre, Gdansk, Poland.
5) Section for Functional Genetics at the Institute of Human Genetics, Universität zu Lübeck, Lübeck, Germany
Worldconference 2019, Germany and Netherlands, Bad NeuenAhr, published on 31 jul. 2019
- Nieuws
- Evenementen
Failed to execute the [velocity] macro. Cause: [null]. Click on this message for details.
org.xwiki.rendering.macro.MacroExecutionException: Failed to evaluate Velocity Macro for content [{{html clean="false"}} ## we need clean="false" because we want to display the raw content
#set($supportGroupClassname = 'WaihonaCode.supportGroupClass')
#set($federationQueryDef = "from doc.object($supportGroupClassname) as sup where sup.Code = :thisFederation")
#set($supportGroupQueryDef = "from doc.object($supportGroupClassname) as sup where sup.language like :thisLanguage and sup.collaboratonGroup = :thisFederation")
## First determine page for 'federation' to show when multiple options are found
## $defaultSupportGroupCode is a variable set in the community specific skin, layoutExtraVars.vm
## at feb 2021 we have 3 community specific skins; cdlsSkin, waihonapediaSkin and wbsSkin
#set($federationRefList = $services.query.xwql($federationQueryDef).bindValue('thisFederation', $defaultSupportGroupCode).execute())
#foreach($federationDocRef in $federationRefList)
##set($ifNotFoundGroupRef = 'WaihonaPartners.cdlsworldfederation.WebHome')
#set($ifNotFoundGroupRef = $federationDocRef )
#end
##set($ifMultipleGroupRef = 'WaihonaPartners.groupChoice')
#set($ifMultipleGroupRef = $ifNotFoundGroupRef)
#set($markActive = '')
##set($classNameForActive = 'WaihonaCode.themeRoomClass')
#set($classNameForActive = $supportGroupClassname)
#if($doc.getObject($classNameForActive))
#set($markActive = 'class="active"')
#end
#if($markActive == '' && $doc.getFullName().startsWith("WaihonaPartners") && !$doc.getFullName().contains("events"))
#set($markActive = 'class="active"')
#end
#if($isGuest)
#if($supportGroupCode != $defaultSupportGroupCode)
#set( $supportGroupQueryByCode ="from doc.object($supportGroupClass) as sgroups where sgroups.Code = :sgroupcode" )
#set( $supportGroupList = $services.query.xwql("$supportGroupQueryByCode").bindValue("sgroupcode", $supportGroupCode).addFilter("unique").execute())
#foreach($supportGroupDocRef in $supportGroupList)
#set($groupDoc = $xwiki.getDocument($supportGroupDocRef))
#set($supportGroupRef = $supportGroupDocRef)
#end
#else
#set($supportGroupRefList = $services.query.xwql($supportGroupQueryDef).bindValue('thisFederation', $defaultSupportGroupCode).bindValue('thisLanguage').literal("${context.language}").anyChars().query().execute())
#if($supportGroupRefList.size() == 1 ) ##we found a unique supportgroup, present that page
#foreach($thisSupportGroupRef in $supportGroupRefList)
#set($supportGroupRef=$thisSupportGroupRef)
#end
#elseif($supportGroupRefList.size() > 1) ## we need to show user a list of supportgroups
#set($supportGroupRef=$ifMultipleGroupRef)
#else ## No group found, we need to show a defined supportgroup
#set($supportGroupRef=$ifNotFoundGroupRef)
#end
#end
#elseif($isApproved)
##$pwsUserContext
#set($supportGroupRef = $pwsUserContext.waiSupportGroupDocRef)
#else
#set($supportGroupRef=$ifNotFoundGroupRef)
#end
#set($targetURL=$xwiki.getDocument($supportGroupRef).getURL() )
##set($menuLabel=$xwiki.getDocument($supportGroupRef).getPlainTitle() )
#set($menuLabel=$services.localization.render('waihonapedia.topmenu.meet.label'))
<li $markActive>
<a href="$targetURL" class="icon-navbar">$menuLabel</a>
</li>
{{/html}}]
at org.xwiki.rendering.internal.macro.velocity.VelocityMacro.evaluateString(VelocityMacro.java:186)
at org.xwiki.rendering.internal.macro.velocity.VelocityMacro.evaluateString(VelocityMacro.java:60)
at org.xwiki.rendering.macro.script.AbstractScriptMacro.evaluateBlock(AbstractScriptMacro.java:279)
at org.xwiki.rendering.macro.script.AbstractScriptMacro.execute(AbstractScriptMacro.java:182)
at org.xwiki.rendering.macro.script.AbstractScriptMacro.execute(AbstractScriptMacro.java:58)
at org.xwiki.rendering.internal.transformation.macro.MacroTransformation.transform(MacroTransformation.java:311)
at org.xwiki.rendering.internal.transformation.DefaultRenderingContext.transformInContext(DefaultRenderingContext.java:183)
at org.xwiki.rendering.async.internal.block.AbstractBlockAsyncRenderer.transform(AbstractBlockAsyncRenderer.java:76)
at org.xwiki.rendering.async.internal.block.DefaultBlockAsyncRenderer.tranform(DefaultBlockAsyncRenderer.java:154)
at org.xwiki.rendering.async.internal.block.DefaultBlockAsyncRenderer.execute(DefaultBlockAsyncRenderer.java:137)
at org.xwiki.rendering.async.internal.block.AbstractBlockAsyncRenderer.render(AbstractBlockAsyncRenderer.java:157)
at org.xwiki.uiextension.internal.WikiUIExtension.render(WikiUIExtension.java:200)
at org.xwiki.rendering.async.internal.block.DefaultBlockAsyncRendererExecutor$DecoratorWrapper.render(DefaultBlockAsyncRendererExecutor.java:67)
at org.xwiki.rendering.async.internal.block.DefaultBlockAsyncRendererExecutor$DecoratorWrapper.render(DefaultBlockAsyncRendererExecutor.java:49)
at org.xwiki.rendering.async.internal.DefaultAsyncRendererExecutor.lambda$syncRender$0(DefaultAsyncRendererExecutor.java:284)
at com.xpn.xwiki.internal.security.authorization.DefaultAuthorExecutor.call(DefaultAuthorExecutor.java:98)
at org.xwiki.rendering.async.internal.DefaultAsyncRendererExecutor.syncRender(DefaultAsyncRendererExecutor.java:284)
at org.xwiki.rendering.async.internal.DefaultAsyncRendererExecutor.render(DefaultAsyncRendererExecutor.java:267)
at org.xwiki.rendering.async.internal.block.DefaultBlockAsyncRendererExecutor.execute(DefaultBlockAsyncRendererExecutor.java:125)
at org.xwiki.rendering.async.internal.block.DefaultBlockAsyncRendererExecutor.execute(DefaultBlockAsyncRendererExecutor.java:113)
at org.xwiki.uiextension.internal.AbstractWikiUIExtension.execute(AbstractWikiUIExtension.java:101)
at org.xwiki.uiextension.internal.AbstractWikiUIExtension.execute(AbstractWikiUIExtension.java:89)
at jdk.internal.reflect.GeneratedMethodAccessor2443.invoke(Unknown Source)
at java.base/jdk.internal.reflect.DelegatingMethodAccessorImpl.invoke(DelegatingMethodAccessorImpl.java:43)
at java.base/java.lang.reflect.Method.invoke(Method.java:566)
at org.apache.velocity.util.introspection.UberspectImpl$VelMethodImpl.doInvoke(UberspectImpl.java:571)
at org.apache.velocity.util.introspection.UberspectImpl$VelMethodImpl.invoke(UberspectImpl.java:554)
at org.apache.velocity.runtime.parser.node.ASTMethod.execute(ASTMethod.java:221)
at org.apache.velocity.runtime.parser.node.ASTReference.execute(ASTReference.java:368)
at org.apache.velocity.runtime.parser.node.ASTReference.value(ASTReference.java:704)
at org.apache.velocity.runtime.parser.node.ASTExpression.value(ASTExpression.java:75)
at org.apache.velocity.runtime.parser.node.ASTMethod.execute(ASTMethod.java:167)
at org.apache.velocity.runtime.parser.node.ASTReference.execute(ASTReference.java:368)
at org.apache.velocity.runtime.parser.node.ASTReference.render(ASTReference.java:492)
at org.apache.velocity.runtime.parser.node.ASTBlock.render(ASTBlock.java:147)
at org.apache.velocity.runtime.parser.node.ASTIfStatement.render(ASTIfStatement.java:171)
at org.apache.velocity.runtime.parser.node.ASTBlock.render(ASTBlock.java:147)
at org.apache.velocity.runtime.directive.Foreach.renderBlock(Foreach.java:309)
at org.apache.velocity.runtime.directive.Foreach.render(Foreach.java:279)
at org.apache.velocity.runtime.parser.node.ASTDirective.render(ASTDirective.java:304)
at org.apache.velocity.runtime.parser.node.SimpleNode.render(SimpleNode.java:439)
at org.apache.velocity.Template.merge(Template.java:358)
at org.apache.velocity.Template.merge(Template.java:262)
at org.xwiki.velocity.internal.InternalVelocityEngine.evaluate(InternalVelocityEngine.java:225)
at org.xwiki.velocity.internal.InternalVelocityEngine.evaluate(InternalVelocityEngine.java:173)
at org.xwiki.rendering.internal.macro.velocity.VelocityMacro.evaluateString(VelocityMacro.java:177)
at org.xwiki.rendering.internal.macro.velocity.VelocityMacro.evaluateString(VelocityMacro.java:60)
at org.xwiki.rendering.macro.script.AbstractScriptMacro.evaluateBlock(AbstractScriptMacro.java:279)
at org.xwiki.rendering.macro.script.AbstractScriptMacro.execute(AbstractScriptMacro.java:182)
at org.xwiki.rendering.macro.script.AbstractScriptMacro.execute(AbstractScriptMacro.java:58)
at org.xwiki.rendering.internal.transformation.macro.MacroTransformation.transform(MacroTransformation.java:311)
at org.xwiki.rendering.internal.transformation.DefaultRenderingContext.transformInContext(DefaultRenderingContext.java:183)
at org.xwiki.rendering.async.internal.block.AbstractBlockAsyncRenderer.transform(AbstractBlockAsyncRenderer.java:76)
at org.xwiki.rendering.async.internal.block.DefaultBlockAsyncRenderer.tranform(DefaultBlockAsyncRenderer.java:154)
at org.xwiki.rendering.async.internal.block.DefaultBlockAsyncRenderer.execute(DefaultBlockAsyncRenderer.java:137)
at org.xwiki.rendering.async.internal.block.AbstractBlockAsyncRenderer.render(AbstractBlockAsyncRenderer.java:157)
at org.xwiki.uiextension.internal.WikiUIExtension.render(WikiUIExtension.java:200)
at org.xwiki.rendering.async.internal.block.DefaultBlockAsyncRendererExecutor$DecoratorWrapper.render(DefaultBlockAsyncRendererExecutor.java:67)
at org.xwiki.rendering.async.internal.block.DefaultBlockAsyncRendererExecutor$DecoratorWrapper.render(DefaultBlockAsyncRendererExecutor.java:49)
at org.xwiki.rendering.async.internal.DefaultAsyncRendererExecutor.lambda$syncRender$0(DefaultAsyncRendererExecutor.java:284)
at com.xpn.xwiki.internal.security.authorization.DefaultAuthorExecutor.call(DefaultAuthorExecutor.java:98)
at org.xwiki.rendering.async.internal.DefaultAsyncRendererExecutor.syncRender(DefaultAsyncRendererExecutor.java:284)
at org.xwiki.rendering.async.internal.DefaultAsyncRendererExecutor.render(DefaultAsyncRendererExecutor.java:267)
at org.xwiki.rendering.async.internal.block.DefaultBlockAsyncRendererExecutor.execute(DefaultBlockAsyncRendererExecutor.java:125)
at org.xwiki.rendering.async.internal.block.DefaultBlockAsyncRendererExecutor.execute(DefaultBlockAsyncRendererExecutor.java:113)
at org.xwiki.uiextension.internal.AbstractWikiUIExtension.execute(AbstractWikiUIExtension.java:101)
at org.xwiki.uiextension.internal.AbstractWikiUIExtension.execute(AbstractWikiUIExtension.java:89)
at jdk.internal.reflect.GeneratedMethodAccessor2443.invoke(Unknown Source)
at java.base/jdk.internal.reflect.DelegatingMethodAccessorImpl.invoke(DelegatingMethodAccessorImpl.java:43)
at java.base/java.lang.reflect.Method.invoke(Method.java:566)
at org.apache.velocity.util.introspection.UberspectImpl$VelMethodImpl.doInvoke(UberspectImpl.java:571)
at org.apache.velocity.util.introspection.UberspectImpl$VelMethodImpl.invoke(UberspectImpl.java:554)
at org.apache.velocity.runtime.parser.node.ASTMethod.execute(ASTMethod.java:221)
at org.apache.velocity.runtime.parser.node.ASTReference.execute(ASTReference.java:368)
at org.apache.velocity.runtime.parser.node.ASTReference.value(ASTReference.java:704)
at org.apache.velocity.runtime.parser.node.ASTExpression.value(ASTExpression.java:75)
at org.apache.velocity.runtime.parser.node.ASTMethod.execute(ASTMethod.java:167)
at org.apache.velocity.runtime.parser.node.ASTReference.execute(ASTReference.java:368)
at org.apache.velocity.runtime.parser.node.ASTReference.render(ASTReference.java:492)
at org.apache.velocity.runtime.parser.node.ASTBlock.render(ASTBlock.java:147)
at org.apache.velocity.runtime.directive.Foreach.renderBlock(Foreach.java:309)
at org.apache.velocity.runtime.directive.Foreach.render(Foreach.java:279)
at org.apache.velocity.runtime.parser.node.ASTDirective.render(ASTDirective.java:304)
at org.apache.velocity.runtime.parser.node.ASTBlock.render(ASTBlock.java:147)
at org.apache.velocity.runtime.directive.VelocimacroProxy.render(VelocimacroProxy.java:218)
at org.apache.velocity.runtime.directive.RuntimeMacro.render(RuntimeMacro.java:331)
at org.apache.velocity.runtime.directive.RuntimeMacro.render(RuntimeMacro.java:261)
at org.apache.velocity.runtime.parser.node.ASTDirective.render(ASTDirective.java:304)
at org.apache.velocity.runtime.parser.node.SimpleNode.render(SimpleNode.java:439)
at org.apache.velocity.Template.merge(Template.java:358)
at org.apache.velocity.Template.merge(Template.java:262)
at org.xwiki.velocity.internal.InternalVelocityEngine.evaluate(InternalVelocityEngine.java:225)
at com.xpn.xwiki.internal.template.VelocityTemplateEvaluator.evaluateContent(VelocityTemplateEvaluator.java:105)
at com.xpn.xwiki.internal.template.TemplateAsyncRenderer.evaluateContent(TemplateAsyncRenderer.java:219)
at com.xpn.xwiki.internal.template.TemplateAsyncRenderer.renderVelocity(TemplateAsyncRenderer.java:174)
at com.xpn.xwiki.internal.template.TemplateAsyncRenderer.render(TemplateAsyncRenderer.java:135)
at com.xpn.xwiki.internal.template.TemplateAsyncRenderer.render(TemplateAsyncRenderer.java:54)
at org.xwiki.rendering.async.internal.DefaultAsyncRendererExecutor.lambda$syncRender$0(DefaultAsyncRendererExecutor.java:284)
at com.xpn.xwiki.internal.security.authorization.DefaultAuthorExecutor.call(DefaultAuthorExecutor.java:98)
at org.xwiki.rendering.async.internal.DefaultAsyncRendererExecutor.syncRender(DefaultAsyncRendererExecutor.java:284)
at org.xwiki.rendering.async.internal.DefaultAsyncRendererExecutor.render(DefaultAsyncRendererExecutor.java:267)
at org.xwiki.rendering.async.internal.block.DefaultBlockAsyncRendererExecutor.render(DefaultBlockAsyncRendererExecutor.java:154)
at com.xpn.xwiki.internal.template.InternalTemplateManager.render(InternalTemplateManager.java:904)
at com.xpn.xwiki.internal.template.InternalTemplateManager.renderFromSkin(InternalTemplateManager.java:866)
at com.xpn.xwiki.internal.template.InternalTemplateManager.render(InternalTemplateManager.java:853)
at com.xpn.xwiki.internal.template.InternalTemplateManager.renderNoException(InternalTemplateManager.java:808)
at com.xpn.xwiki.internal.template.InternalTemplateManager.renderNoException(InternalTemplateManager.java:800)
at com.xpn.xwiki.internal.template.DefaultTemplateManager.renderNoException(DefaultTemplateManager.java:79)
at com.xpn.xwiki.internal.template.DefaultTemplateManager.renderNoException(DefaultTemplateManager.java:73)
at org.xwiki.template.script.TemplateScriptService.render(TemplateScriptService.java:54)
at jdk.internal.reflect.GeneratedMethodAccessor2445.invoke(Unknown Source)
at java.base/jdk.internal.reflect.DelegatingMethodAccessorImpl.invoke(DelegatingMethodAccessorImpl.java:43)
at java.base/java.lang.reflect.Method.invoke(Method.java:566)
at org.apache.velocity.util.introspection.UberspectImpl$VelMethodImpl.doInvoke(UberspectImpl.java:571)
at org.apache.velocity.util.introspection.UberspectImpl$VelMethodImpl.invoke(UberspectImpl.java:554)
at org.apache.velocity.runtime.parser.node.ASTMethod.execute(ASTMethod.java:221)
at org.apache.velocity.runtime.parser.node.ASTReference.execute(ASTReference.java:368)
at org.apache.velocity.runtime.parser.node.ASTReference.render(ASTReference.java:492)
at org.apache.velocity.runtime.parser.node.ASTBlock.render(ASTBlock.java:147)
at org.apache.velocity.runtime.directive.VelocimacroProxy.render(VelocimacroProxy.java:218)
at org.apache.velocity.runtime.directive.RuntimeMacro.render(RuntimeMacro.java:331)
at org.apache.velocity.runtime.directive.RuntimeMacro.render(RuntimeMacro.java:261)
at org.apache.velocity.runtime.parser.node.ASTDirective.render(ASTDirective.java:304)
at org.apache.velocity.runtime.parser.node.ASTBlock.render(ASTBlock.java:147)
at org.apache.velocity.runtime.parser.node.ASTIfStatement.render(ASTIfStatement.java:171)
at org.apache.velocity.runtime.parser.node.ASTBlock.render(ASTBlock.java:147)
at org.apache.velocity.runtime.parser.node.SimpleNode.render(SimpleNode.java:439)
at org.apache.velocity.runtime.parser.node.ASTIfStatement.render(ASTIfStatement.java:190)
at org.apache.velocity.runtime.parser.node.SimpleNode.render(SimpleNode.java:439)
at org.apache.velocity.Template.merge(Template.java:358)
at org.apache.velocity.Template.merge(Template.java:262)
at org.xwiki.velocity.internal.InternalVelocityEngine.evaluate(InternalVelocityEngine.java:225)
at com.xpn.xwiki.internal.template.VelocityTemplateEvaluator.evaluateContent(VelocityTemplateEvaluator.java:105)
at com.xpn.xwiki.internal.template.TemplateAsyncRenderer.evaluateContent(TemplateAsyncRenderer.java:219)
at com.xpn.xwiki.internal.template.TemplateAsyncRenderer.renderVelocity(TemplateAsyncRenderer.java:174)
at com.xpn.xwiki.internal.template.TemplateAsyncRenderer.render(TemplateAsyncRenderer.java:135)
at com.xpn.xwiki.internal.template.TemplateAsyncRenderer.render(TemplateAsyncRenderer.java:54)
at org.xwiki.rendering.async.internal.DefaultAsyncRendererExecutor.lambda$syncRender$0(DefaultAsyncRendererExecutor.java:284)
at com.xpn.xwiki.internal.security.authorization.DefaultAuthorExecutor.call(DefaultAuthorExecutor.java:98)
at org.xwiki.rendering.async.internal.DefaultAsyncRendererExecutor.syncRender(DefaultAsyncRendererExecutor.java:284)
at org.xwiki.rendering.async.internal.DefaultAsyncRendererExecutor.render(DefaultAsyncRendererExecutor.java:267)
at org.xwiki.rendering.async.internal.block.DefaultBlockAsyncRendererExecutor.render(DefaultBlockAsyncRendererExecutor.java:154)
at com.xpn.xwiki.internal.template.InternalTemplateManager.render(InternalTemplateManager.java:904)
at com.xpn.xwiki.internal.template.InternalTemplateManager.renderFromSkin(InternalTemplateManager.java:866)
at com.xpn.xwiki.internal.template.InternalTemplateManager.renderFromSkin(InternalTemplateManager.java:846)
at com.xpn.xwiki.internal.template.InternalTemplateManager.render(InternalTemplateManager.java:832)
at com.xpn.xwiki.internal.template.DefaultTemplateManager.render(DefaultTemplateManager.java:91)
at com.xpn.xwiki.internal.template.DefaultTemplateManager.render(DefaultTemplateManager.java:85)
at com.xpn.xwiki.XWiki.evaluateTemplate(XWiki.java:2565)
at com.xpn.xwiki.web.Utils.parseTemplate(Utils.java:180)
at com.xpn.xwiki.web.XWikiAction.execute(XWikiAction.java:651)
at com.xpn.xwiki.web.XWikiAction.execute(XWikiAction.java:339)
at com.xpn.xwiki.web.LegacyActionServlet.service(LegacyActionServlet.java:108)
at javax.servlet.http.HttpServlet.service(HttpServlet.java:764)
at org.apache.catalina.core.ApplicationFilterChain.internalDoFilter(ApplicationFilterChain.java:232)
at org.apache.catalina.core.ApplicationFilterChain.doFilter(ApplicationFilterChain.java:167)
at com.xpn.xwiki.web.ActionFilter.doFilter(ActionFilter.java:122)
at org.apache.catalina.core.ApplicationFilterChain.internalDoFilter(ApplicationFilterChain.java:194)
at org.apache.catalina.core.ApplicationFilterChain.doFilter(ApplicationFilterChain.java:167)
at org.xwiki.wysiwyg.filter.ConversionFilter.doFilter(ConversionFilter.java:61)
at org.apache.catalina.core.ApplicationFilterChain.internalDoFilter(ApplicationFilterChain.java:194)
at org.apache.catalina.core.ApplicationFilterChain.doFilter(ApplicationFilterChain.java:167)
at org.apache.tomcat.websocket.server.WsFilter.doFilter(WsFilter.java:52)
at org.apache.catalina.core.ApplicationFilterChain.internalDoFilter(ApplicationFilterChain.java:194)
at org.apache.catalina.core.ApplicationFilterChain.doFilter(ApplicationFilterChain.java:167)
at org.xwiki.container.servlet.filters.internal.SetHTTPHeaderFilter.doFilter(SetHTTPHeaderFilter.java:63)
at org.apache.catalina.core.ApplicationFilterChain.internalDoFilter(ApplicationFilterChain.java:194)
at org.apache.catalina.core.ApplicationFilterChain.doFilter(ApplicationFilterChain.java:167)
at org.xwiki.resource.servlet.RoutingFilter.doFilter(RoutingFilter.java:132)
at org.apache.catalina.core.ApplicationFilterChain.internalDoFilter(ApplicationFilterChain.java:194)
at org.apache.catalina.core.ApplicationFilterChain.doFilter(ApplicationFilterChain.java:167)
at org.xwiki.container.servlet.filters.internal.SavedRequestRestorerFilter.doFilter(SavedRequestRestorerFilter.java:208)
at org.apache.catalina.core.ApplicationFilterChain.internalDoFilter(ApplicationFilterChain.java:194)
at org.apache.catalina.core.ApplicationFilterChain.doFilter(ApplicationFilterChain.java:167)
at org.xwiki.container.servlet.filters.internal.SetCharacterEncodingFilter.doFilter(SetCharacterEncodingFilter.java:111)
at org.apache.catalina.core.ApplicationFilterChain.internalDoFilter(ApplicationFilterChain.java:194)
at org.apache.catalina.core.ApplicationFilterChain.doFilter(ApplicationFilterChain.java:167)
at org.apache.catalina.core.StandardWrapperValve.invoke(StandardWrapperValve.java:202)
at org.apache.catalina.core.StandardContextValve.invoke(StandardContextValve.java:97)
at org.apache.catalina.authenticator.AuthenticatorBase.invoke(AuthenticatorBase.java:544)
at org.apache.catalina.core.StandardHostValve.invoke(StandardHostValve.java:143)
at org.apache.catalina.valves.ErrorReportValve.invoke(ErrorReportValve.java:81)
at org.apache.catalina.valves.AbstractAccessLogValve.invoke(AbstractAccessLogValve.java:698)
at org.apache.catalina.core.StandardEngineValve.invoke(StandardEngineValve.java:78)
at org.apache.catalina.connector.CoyoteAdapter.service(CoyoteAdapter.java:364)
at org.apache.coyote.http11.Http11Processor.service(Http11Processor.java:624)
at org.apache.coyote.AbstractProcessorLight.process(AbstractProcessorLight.java:65)
at org.apache.coyote.AbstractProtocol$ConnectionHandler.process(AbstractProtocol.java:831)
at org.apache.tomcat.util.net.NioEndpoint$SocketProcessor.doRun(NioEndpoint.java:1651)
at org.apache.tomcat.util.net.SocketProcessorBase.run(SocketProcessorBase.java:49)
at java.base/java.util.concurrent.ThreadPoolExecutor.runWorker(ThreadPoolExecutor.java:1128)
at java.base/java.util.concurrent.ThreadPoolExecutor$Worker.run(ThreadPoolExecutor.java:628)
at org.apache.tomcat.util.threads.TaskThread$WrappingRunnable.run(TaskThread.java:61)
at java.base/java.lang.Thread.run(Thread.java:829)
Caused by: org.xwiki.velocity.XWikiVelocityException: Failed to evaluate content with namespace [xwiki:WaihonaBase.uixAllInformationTopMenu^XWiki.UIExtensionClass[1]]
at org.xwiki.velocity.internal.InternalVelocityEngine.evaluate(InternalVelocityEngine.java:227)
at org.xwiki.rendering.internal.macro.velocity.VelocityMacro.evaluateString(VelocityMacro.java:168)
... 193 more
Caused by: org.apache.velocity.exception.MethodInvocationException: Invocation of method 'execute' in class org.xwiki.query.internal.ScriptQuery threw exception org.xwiki.query.QueryException: Exception while executing query. Query statement = [ select doc.fullName from XWikiDocument as doc , BaseObject as sgroups , com.xpn.xwiki.objects.StringProperty as sgroups_Code1 where ( sgroups_Code1.value = :sgroupcode ) and doc.fullName=sgroups.name and sgroups.className='WaihonaCode.supportGroupClass' and sgroups_Code1.id.id=sgroups.id and sgroups_Code1.id.name='Code' ] at xwiki:WaihonaBase.uixAllInformationTopMenu[line 27, column 139]
at org.apache.velocity.runtime.parser.node.ASTMethod.handleInvocationException(ASTMethod.java:308)
at org.apache.velocity.runtime.parser.node.ASTMethod.execute(ASTMethod.java:235)
at org.apache.velocity.runtime.parser.node.ASTReference.execute(ASTReference.java:368)
at org.apache.velocity.runtime.parser.node.ASTReference.value(ASTReference.java:704)
at org.apache.velocity.runtime.parser.node.ASTExpression.value(ASTExpression.java:75)
at org.apache.velocity.runtime.parser.node.ASTSetDirective.render(ASTSetDirective.java:242)
at org.apache.velocity.runtime.parser.node.ASTBlock.render(ASTBlock.java:147)
at org.apache.velocity.runtime.parser.node.ASTIfStatement.render(ASTIfStatement.java:171)
at org.apache.velocity.runtime.parser.node.ASTBlock.render(ASTBlock.java:147)
at org.apache.velocity.runtime.parser.node.ASTIfStatement.render(ASTIfStatement.java:171)
at org.apache.velocity.runtime.parser.node.SimpleNode.render(SimpleNode.java:439)
at org.apache.velocity.Template.merge(Template.java:358)
at org.apache.velocity.Template.merge(Template.java:262)
at org.xwiki.velocity.internal.InternalVelocityEngine.evaluate(InternalVelocityEngine.java:225)
... 194 more
Caused by: org.xwiki.query.QueryException: Exception while executing query. Query statement = [ select doc.fullName from XWikiDocument as doc , BaseObject as sgroups , com.xpn.xwiki.objects.StringProperty as sgroups_Code1 where ( sgroups_Code1.value = :sgroupcode ) and doc.fullName=sgroups.name and sgroups.className='WaihonaCode.supportGroupClass' and sgroups_Code1.id.id=sgroups.id and sgroups_Code1.id.name='Code' ]
at com.xpn.xwiki.store.hibernate.query.HqlQueryExecutor.execute(HqlQueryExecutor.java:184)
at org.xwiki.query.internal.DefaultQueryExecutorManager.execute(DefaultQueryExecutorManager.java:72)
at org.xwiki.query.internal.DefaultQuery.execute(DefaultQuery.java:306)
at org.xwiki.query.xwql.internal.XWQLQueryExecutor.execute(XWQLQueryExecutor.java:117)
at org.xwiki.query.internal.DefaultQueryExecutorManager.execute(DefaultQueryExecutorManager.java:72)
at org.xwiki.query.internal.SecureQueryExecutorManager.execute(SecureQueryExecutorManager.java:67)
at org.xwiki.query.internal.DefaultQuery.execute(DefaultQuery.java:306)
at org.xwiki.query.internal.ScriptQuery.execute(ScriptQuery.java:276)
at jdk.internal.reflect.GeneratedMethodAccessor2457.invoke(Unknown Source)
at java.base/jdk.internal.reflect.DelegatingMethodAccessorImpl.invoke(DelegatingMethodAccessorImpl.java:43)
at java.base/java.lang.reflect.Method.invoke(Method.java:566)
at org.apache.velocity.util.introspection.UberspectImpl$VelMethodImpl.doInvoke(UberspectImpl.java:571)
at org.apache.velocity.util.introspection.UberspectImpl$VelMethodImpl.invoke(UberspectImpl.java:554)
at org.apache.velocity.runtime.parser.node.ASTMethod.execute(ASTMethod.java:221)
... 206 more
Caused by: com.xpn.xwiki.XWikiException: Error number 0 in 3: Exception while hibernate execute
at com.xpn.xwiki.store.XWikiHibernateBaseStore.execute(XWikiHibernateBaseStore.java:835)
at com.xpn.xwiki.store.XWikiHibernateBaseStore.executeRead(XWikiHibernateBaseStore.java:902)
at com.xpn.xwiki.store.hibernate.query.HqlQueryExecutor.execute(HqlQueryExecutor.java:169)
... 219 more
Caused by: java.lang.NullPointerException