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Reglan Use


Caregiver to 13 yr. old male states concern that the time frame of administration of Reglan is not allowing child to receive it at school and behaviors are escalating. Can Reglan be taken at 8:30 am and 10:30 am if this coincides with meals?

Answer of our experts

Reglan should be taken 15 to 30 minutes before major meals. This is obviously not always possible. 15 minutes before is probably acceptable, and it will have some effect taken at the beginning of the meal. It is not clear, however, that a lack of preceding (pre-meal) Reglan will have an effect on intake or behavior. It should have more of an effect on emptying and after-meal reflux and vomiting. The reflux, however, could affect behavior afterwards

DP/TK 7-13-10

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Consider always gastro-oesophageal reflux disease (GORD) in any individual with CdLS owing to its frequency and wide variability in presentation, which includes challenging behaviour.
Modification of nutrition and proton pump inhibitors (PPI) are the first-line treatments of GORD. Anti-reflux medications need to be used to their maximum dosage. Surgical interventions for GORD should be limited to those individuals with CdLS in whom nutritional and medical treatments have been unsuccessful or airway safety is at risk.
If GORD symptoms persist, endoscopy should be strongly considered whilst an individual with CdLS is still in paediatric care.
Surveillance for Barrett’s Oesophagus needs to be discussed with and decided together with the family, balancing the potential gain in health and burden for the individual with CdLS.

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