Sleep

Sleep

Sleep-related difficulties are very common in CdLS and can begin as early as infancy (¹³⁵). Difficulties can include insomnia (difficulty falling and/or staying asleep), apnoea (breathing temporarily stops during sleep), daytime drowsiness and frequent daytime napping (⁹⁰,¹³³,¹³⁴,¹³⁵,¹³⁶).

Approximately 60% of individuals with CdLS are affected by insomnia and some affected individuals are reported to go for several days without sleep (¹³⁵). Snoring is also fairly common in CdLS and can lead to daytime drowsiness (¹³⁴,¹³⁶). Sleep-related difficulties in individuals with CdLS can have serious consequences. Behavioural sleep interventions and melatonin can be helpful in treating sleep problems in CdLS (R49). Sleep-related difficulties are less common in adults with CdLS. Research suggests that sleep difficulties spontaneously improve over time.

Antonie D. Kline, Joanna F. Moss, […]Raoul C. Hennekam

_{Adapted from: Kline, A. D., Moss, J. F., Selicorni, A., Bisgaard, A., Deardorff, M. A., Gillett, P. M., Ishman, S. L., Kerr, L. M., Levin, A. V., Mulder, P. A., Ramos, F. J., Wierzba, J., Ajmone, P.F., Axtell, D., Blagowidow, N., Cereda, A., Costantino, A., Cormier-Daire, V., FitzPatrick, D., Grados, M., Groves, L., Guthrie, W., Huisman, S., Kaiser, F. J., Koekkoek, G., Levis, M., Mariani, M., McCleery, J. P., Menke, L. A., Metrena, A., O’Connor, J., Oliver, C., Pie, J., Piening, S., Potter, C. J., Quaglio, A. L., Redeker, E., Richman, D., Rigamonti, C., Shi, A., Tümer, Z., Van Balkom, I. D. C. and Hennekam, R. C. (2018).}

Source:

Diagnosis and management in Cornelia de Lange Syndrome: First international consensus statement. Nature Reviews Genetics, 19, 649-666, published on 11 jul. 2018

Sidehistorie

Senest ændret af Gerritjan Koekkoek den 2022/09/29 16:10

Oprettet af Gerritjan Koekkoek den 2019/03/27 15:09