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Heredity and level of affectedness with CdLS
Question
What are the possibilities for an individual with CdLS to have a child with CdLS? If they do, will that child most likely show a similar level of affectedness?
Answer of our experts
Individuals with CdLS are likely to be the more mildly affected if they are able to achieve reproduction. This type is thought to be due to a dominant gene. This means that the individual with CdLS has a 50% chance, in each reproductive event, to have a child with CdLS. The child may be similarly affected or more severely affected than the parent. LJ (4-10-01) Most individuals with CdLS should be considered to be fertile, unless a male with undescended testicles. Females need to be protected if in an unsupervised situation
TK 7-13-10
Approved byClinical Advisory Board (CAB)
Answer is checked and valid for
Recommendation(s)
Can individuals with CdLS have children?
R20
Sexual education appropriate to the level of understanding should be offered, and contraception management should follow local standard for the general population.
R21
Hysterectomy is indicated if abnormally heavy bleeding at menstruation is present and does not respond to medical treatment.
